THE ROLE OF TRANSCRIPTOMICS: PHYSIOLOGICAL EQUIVALENCE BASED ON GENE EXPRESSION PROFILES

Authors : Shiori Miura, Takehiro Himaki, Junko Takahashi, Hitoshi Iwahashi
Disciplines : Molecular biology
Keywords : gene expression, microarray, RNA-sequence, transcriptome
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Abstract

DNA microarray and RNA sequencing platforms enable us to simultaneously measure the expression levels of a large number of genes. These platforms serve as emerging techniques for the comprehensive understanding of gene expression and profiling and are generally used to detect genes that are differentially expressed in response to several conditions including the environment, stress, and genetic background. Therefore, these can function as tools to understand biological responses. Large-scale gene expression studies are also useful in biological experiments to confirm the assumptions of models and data uniformity. Accordingly, these approaches are imperative for ensuring the accuracy of investigations of the <em>in vivo</em> vital reaction. In this review, we describe the role of transcriptomics in the evaluation of physiological equality through gene expression profiles.

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